Keller Building is home to programs in the College of Education, Smeal College of Business and College of Health and Human Development.
The Department of Recreation, Park, and Tourism Management's Golf Teaching and Research Center (GTRC) is located in the lower level. The Department of Health Policy and Administration's Master of Health Administration offices are located on the first floor. The College of Education's Learning and Performance Systems is on the third and fourth floor, along with the Goodling Institute for Research in Family Literacy, the Institute for the Study of Adult Literacy and Professional Personnel Development Center for Career and Technical Education. Keller Building is also home to the College of the Liberal Arts' School of Labor and Employment Relations.